Drug-induced arrhythmias
نویسندگان
چکیده
منابع مشابه
Channel structure and drug-induced cardiac arrhythmias.
E lectrical activity underlies the control of the frequency, strength, and duration of contraction of the heart. During the cardiac cycle, a regular rhythmic pattern must be established in time-dependent changes in ionic conductances to ensure events that underlie normal cardiac function. Electrical impulses, originating at the sino atrial node are conducted throughout the atria until they conv...
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Drugs often have undesired side effects. In the heart, they can induce lethal arrhythmias such as torsades de pointes. The risk evaluation of a new compound is costly and can take a long time, which often hinders the development of new drugs. Here, we establish a high-resolution, multiscale computational model to quickly assess the cardiac toxicity of new and existing drugs. The input of the mo...
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Precision medicine refers to new treatment and prevention strategies that take individual variability into account. Toward that end, the National Institutes of Health Precision Medicine Initiative envisions supporting a research program to encourage creative approaches to precision medicine, test them rigorously, and ultimately use them to build the evidence base needed to guide clinical practi...
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Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for assessment of drug-induced arrhythmias and are being considered for use under the comprehensive in vitro proarrhythmia assay (CiPA). We studied the effects of 26 drugs and 3 drug combinations on 2 commercially available iPSC-CM types using high-throughput voltage-sensitive dye and microelectrode-array assays being s...
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Risk of severe and fatal ventricular arrhythmias, presenting as Torsade de Pointes (TdP), is increased in congenital and acquired forms of long QT syndromes (LQTS). Drug-induced inhibition of K+ currents, IKs, IKr, IK1, and/or Ito, delay repolarization, prolong QT, and increase the risk of TdP. Drug-induced interference with IKr is the most common cause of acquired LQTS/TdP. Multiple drugs bind...
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ژورنال
عنوان ژورنال: Meditsinskiy sovet = Medical Council
سال: 2021
ISSN: 2658-5790,2079-701X
DOI: 10.21518/2079-701x-2020-21-26-40